Memphis summers are not mild. The combination of ambient temperatures in the mid-90s, high humidity, and the radiative heat from summer pavement creates some of the most demanding conditions a vehicle's cooling system will face anywhere in the country. Add a full car, a loaded trunk, and the AC running continuously, and you've stacked every demand onto the system simultaneously.
The cooling system is the primary summer concern. Coolant degrades over time and loses heat-transfer efficiency — a flush and refill with fresh coolant before summer travel is particularly valuable here. Hoses should be inspected for hardening and cracking (Memphis UV exposure ages rubber faster than many northern climates). The radiator cap should hold its rated pressure. A marginal system that handles short daily drives may fail under the sustained load of a five-hour interstate run to Gulf Shores in August.
Tires need attention too. Underinflation generates heat, and summer pavement temperatures on I-40 can exceed 150°F. A tire that's low going in can fail on the road. Check pressure cold every morning before a long drive, and inspect tread depth with a quarter before any trip over two hours.